Abstract
Exactly ninety-nine years ago, Matilda’s milk and Dr. John Buck’s laboratory accident became one of the most important strides in the history of Brucella vaccines and is considered a success story where “chance favored the prepared mind”. Despite that a century has passed, to this date, there have been no significant advances in the development of superior vaccines, and S19 is still considered to be the best choice in terms of protective efficacy against B. abortus. Here, we discuss lessons learned as well as new approaches to better understand the mechanisms behind enhancing protective efficacy and safety, and their importance in the development of next generation vaccines.
